Skip to main content

TL1 Training Program

RFA for 2015 TL1 program

The application form for the 2015 TL1 program, along with further information and instructions, is now available here.


ICTR’s TL1 Training Program began with the Clinical and Translational Science Award (CTSA) to UW-Madison in September 2007. The goal of the ICTR pre-doctoral TL1 program is to train future clinical and translational leaders and to expose all UW health-care professionals and engineering students to the scientific foundation of this discipline. This training program builds on strong clinical and translational training programs that already exist in the School of Medicine and Public Health, School of Nursing, School of Pharmacy, College of Engineering and School of Veterinary Medicine. Brief biographies and photographs of the current ICTR trainees are below.

Photos and biographies of current TL1 trainees can be viewed below. Information about previous TL1 trainees can be viewed here.

Additional program information can be viewed here (37 KB)


Current TL1 Trainees


Matthew E Brown

Matthew E Brown

Matthew E Brown studies with mentor, Dr. Burlingham, a seasoned expert in T cell biology and transplant immunology, and my thesis research will utilize his expertise to study mechanisms of tolerance of transplanted tissues. My previous research showed that monoclonal T cells specific for peptides of interest maintain their unique T cell receptor (TCR) rearrangement when reprogrammed into iPSCs1. These iPSCs, which serve as a virtually unlimited source of starting material, can then be re-differentiated back into a monoclonal pool of T cells bearing the TCR of interest. Additionally, it was recently shown that these re-differentiated T cells are “rejuvenated”; they bear elongated telomeres and have a more central memory phenotype compared to the input T cells3. We will take advantage of this system to explore therapeutic applications of regulatory T (Treg) cells, which play an important immunomodulatory role in tissue transplantation and in a variety of pathologies.

My research aims include the creation of a novel humanized mouse incorporating syngeneic pediatric thymus, umbilical cord blood, peripheral blood and iPSCs. This model will provide a key tool to investigate the immunogenicity of iPSC-derived tissues--a critical, yet neglected, area of research essential to the realization of iPSCs’ therapeutic potential. Relatedly, I will work to optimize the in vitro derivation of clinically-relevant quantities of re-differentiated monoclonal Tregs for pre-clinical feasibility studies.

Kai D. Ludwig

Kai D. Ludwig

Kai D. Ludwig earned his bachelor’s degree at UW-Madison in Biochemistry. He is pursuing a PhD Minor in Clinical Investigation and the MS/PhD in Medical Physics with Professor Sean B. Fain, PhD. Kai is researching the applications of multi-nuclei Magnetic Resonance Imaging and spectroscopy to F-labeled cell trafficking for the monitoring of cancer immunotherapy and metabolism.

Kate Sprecher

Kate Sprecher

Kate Sprecher earned her masters degree in neuroscience at the University of Otago, New Zealand, and bachelors in neuroscience/physiology at Flinders University, South Australia, where she also earned a diploma in French. She is pursuing a PhD in Neuroscience and a PhD Minor in Clinical Investigation. Kate is mentored by Ruth Benca, MD, PhD, a professor of psychiatry and psychology and director of the Wisconsin Sleep Center. Kate is examining changes in sleeping brain activity and structure across the lifespan, and in neurodegenerative disorders such as Alzheimer’s Disease.

Andrew Voter

Andrew Voter

Andrew Voter received his bachelors degree in Chemistry and Biology at Bucknell University, Lewisburg, PA. He is currently pursuing a PhD Minor in Clinical Investigation, a PhD in the Integrated Program in Biochemistry, and an MD in the Medical Scientist Training Program. Andy is working with Biomolecular Chemistry Professor James Keck, PhD. Andy’s research is focused on small molecule screening toward DNA crosslinks to protect non-cancerous cells during therapy.

Brittany Young

Brittany Young

Brittany Young earned her B.A. in Linguistics and her B.S. in Human Biology with a minor in Mathematics at the University of California - San Diego. She is currently pursuing a combined MD-PhD degree through the University of Wisconsin’s Medical Scientist Training Program and has chosen to pursue her graduate studies through the university’s Neuroscience Training Program. Young joined Dr. Vivek Prabhakaran’s lab in 2011 and now works on collaborative projects with the Neural Interface Technology Research and Optimization lab of Dr. Justin Williams. Her work focuses largely on neurorehabilitation using novel interventional devices and examining neuroplasticity using functional MRI following insults to the brain such as stroke.

<-- back to Career Development Awards page