ICTR Executive Director Allan Brasier has collaborated with Dr. Nizar N. Jarjour, Chief of Allergy, Pulmonary and Critical Care Medicine at UW-Madison, to serve as senior editors of the book Precision Approaches to Heterogeneity in Asthma. It has been published by Springer-Nature as part of the book series Advances in Experimental Medicine and Biology. The book has just been publicly released and is available at https://link.springer.com/book/10.1007/978-3-031-32259-4.
This work includes contributions from 17 recognized experts in asthma from UW-Madison and internationally that advance precision approaches to the complex, multifactorial and heterogenous disease. The work provides state-of-the-art information on clinical phenotypes (endotypes) of asthma, epidemiological manifestations of the disease, and fundamental mechanisms for regional variations in ventilation.
New work on systems approaches to analyzing the findings from studies of inducible phenotypes, and emerging results of biomarker-informed clinical trials, are provided. This work facilitates current understanding of the spectrum of disease etiology, prognosis, and the likelihood of responding to the range of available therapeutic interventions bringing an evidence-based approach to asthma.