Current KL2 Scholar
Scott Nagle, MD, PhD, is an Assistant Professor (CHS) in the UW-Madison Department of Radiology. Nagle’s research focuses on developing magnetic resonance imaging (MRI) biomarkers of lung disease severity and response to treatment, particularly in the setting of cystic fibrosis. Unlike computed tomography (CT), MRI offers the ability to image both lung structure and function and does not involve harmful radiation. Nagle’s hypothesis is that comprehensive lung MRI better discriminates both baseline lung disease severity and treatment response than the existing alternative tests, including the Cystic Fibrosis Questionnaire, chest x-ray, chest CT, and spirometry. If this hypothesis is confirmed, MRI has the potential to extend patient longevity and the time before lung transplant by 1) accelerating the evaluation of the many new drugs that are currently under development and 2) quickly identifying the most effective treatment for each individual patient.
Nagle’s KL2 mentors are Sean Fain, PhD (Department of Medical Physics), Michael Rock, MD (Department of Pediatrics), and Alan Brody, MD (Cincinnati Children’s Hospital Department of Radiology).