University of Wisconsin–Madison

Graduate Program in Clinical Investigation

allergy_test_0The ICTR Graduate Program in Clinical Investigation includes two PhD programs, Clinical Investigation (PhD CI) and Clinical and Translational Science (PhDCTS, formerly the PhD Minor in Clinical Investigation) and an MS in Clinical Investigation. All three degrees share a common didactic foundation encompassing biostatistics, epidemiology, clinical study design, clinical trials conduct, and the ethical and responsible conduct of research.

The PhD CI is an applied degree in which trainees focus on the creation of novel methodologies and tools for translational science within the context of a specific biomedical discipline.

The PhDCTS leverages the core curriculum to give trainees in non-Clinical Investigation PhD programs the skills and tools necessary to move their biomedical research along the translational pathway.

Program Overview Brochure (PDF)

2017 Deadline for MS and PhD Applications Passed (Feb 1)

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  • PhD in Clinical Investigation
    Learning Objectives

    Students earning a PhD in Clinical Investigation must demonstrate distinctive attainment in a specific field and ability for independent investigation, through defense of a research dissertation and through coursework.

    While earning the degree, the PhD student works toward the following learning objectives:

    1. Determine when it is and is not appropriate to use a multidisciplinary patient-oriented research design to investigate a therapeutic problem.
    2. Conceptualize and design multidisciplinary patient-oriented research protocols.
    3. Execute multidisciplinary therapeutic intervention studies.
    4. Interpret and report research findings using the expertise of collaborators in multiple disciplines.
    5. Disseminate knowledge through teaching and mentoring students/trainees.
    6. Lead programs that integrate clinical and translational science across multiple departments, schools and colleges, clinical and research institutes, and healthcare delivery organizations.
    7. Translate research from the laboratory to the clinic through technological innovations, such as drug therapies, medical devices or biological materials (“bench to bedside”).

    ICTR governs the PhD program jointly with representatives of its academic partners; faculty members from each academic partner serve as instructors, advisors, and leaders in the graduate program.

    Reference Materials:

    GPCI Minimum Admissions Requirements (PDF)
    PhD Curriculum (PDF)
    Funding (PDF)

    Updated: 8/5/2016
  • PhD in Clinical and Translational Science
    Learning Objectives

    Doctoral students in Engineering, Nursing, Veterinary Medicine, and other disciplines can declare a PhD focus in Clinical and Translation Science to learn about applications of research to clinical disciplines. A PhDCTS provides students with a general education in interdisciplinary clinical research, while emphasizing a scientific area of graduate study. The PhDCTS is also known as a PhD Minor in Clinical Investigation.

    The PhDCTS requires 10 credits including three required courses and a fourth elective required course:

    Biostatistics and Medical Informatics 541: Introduction to Biostatistics (3 credits, Fall)
    Biostatistics and Medical Informatics 542: Introduction to Clinical Trials I (3 credits, Spring)
    One lecture course in the Responsible Conduct of Research (1-2 credits) selected from an approved list
    Elective courses to reach at least 10 credits total, selected from the following list of options:

    Biostatistics and Medical Informatics 544: Introduction to Clinical Trials II (3 credits, Fall)
    Family Medicine 701: Perspectives in Multidisciplinary Clinical and Translational Research (2 credits, Fall)
    Nursing 705: Seminar in Interdisciplinary Clinical Research Evidence (2 credits, Summer)
    Population Health 797: Introduction to Epidemiology (3 credits, Fall)

    Reference Materials:
    Form to declare CTS focus (PDF)
    Program Requirements (PDF)

    Updated: 12/1/2016
  • MS in Clinical Investigation
    Learning Objectives

    Students in the Masters in Clinical Investigation program formulate a research question, investigate a problem or issue, report the results, and discuss the findings and implications of a study. Courses are complemented by research, culminating in defense of a master’s thesis.

    Before applying to the program, the student meets with a potential faculty advisor to discuss research topics and project ideas that will be needed for the application. After admission, the student has further opportunities to refine the research strategy. During the final year of coursework, the student conducts the research project, and meets frequently with the major advisor, who will monitor progress and provide feedback. Near the end of the final year of coursework, the student completes the project and begins to prepare the thesis manuscript.

    Through coursework and research, the MS student works toward the following learning objectives:

    1. Determine when it is and is not appropriate to use a multidisciplinary patient-oriented research design to investigate a therapeutic problem.
    2. Conceptualize and design multidisciplinary patient-oriented research protocols.
    3. Execute multidisciplinary therapeutic intervention studies.
    4. Interpret and report research findings using the expertise of collaborators in multiple disciplines.
    5. Contribute to the leadership of programs that integrate clinical and translational science across multiple departments, schools and colleges, clinical and research institutes, and healthcare delivery organizations.
    6. Translate research from the laboratory to the clinic through technological innovations, such as drug therapies, medical devices or biological materials (“bench to bedside”), as an active participant in a multidisciplinary clinical research team.

    ICTR governs the MS program jointly with representatives of its academic partners; faculty members from each academic partner serve as instructors, advisors, and leaders in the graduate program.

    Reference Materials:

    GPCI Minimum Admissions Requirements (PDF)
    MS Curriculum (PDF)
    Funding (PDF)

    Updated: 8/5/2016
  • Program Faculty/Major Advisors
    • Sanjay Asthana, MD
      Title/Dept: Professor Geriatrics; Director ADRC; Director GRECC; Assoc. Dir. WI Alzheimer’s Institute
      Research: Alzheimer’s, aging
    • Bruce Barrett, MD, PhD
      Title/Dept:
      Professor Family Medicine, Population Health, Anthropology
      Research: Primary care, especially for special populations
    • David DeMets, PhD
      Title/Dept: Biostats & Medical Informatics
      Research: Clinical trial analysis, sequential methods data monitoring, survival and longitudinal studies
    • Robert Dempsey, MD
      Title/Dept: Professor Neurology; Chairperson Surgery
      Research: Cerebral ischemia, injured brain repair
    • Dorte Dopfer, DVM
      Title/Dept: Professor Vet Medicine, Food Animal Production Medicine
      Research: Veterinary epidemiology, food safety, global health
    • Marina Emborg, MD, PhD
      Title/Dept: Assoc Professor Medical Physics
      Research: Neurodegenerative disorders
    • Amy Fowler, MD, PhD
      Title/Dept: Assistant Professor Radiology
      Research: Molecular imaging biomarkers to assess early therapeutic response for breast cancer in preclinical and translational clinical studies
    • Ronald Gangnon, PhD
      Title/Dept: Associate Professor Biostats & Medical Informatics
      Research: Model selection,  measurement reliability, survival analysis, interim monitoring
    • James Gern, MD
      Title/Dept: Professor Medicine & Pediatrics
      Research: Asthma, interaction between host and viral factors affecting respiratory illness severity
    • Jenny Gumperz, PhD
      Title/Dept: Associate Professor Med Microbiology and Immunology
      Research: Immunology
    • Bryan Heiderscheit, PT, PhD
      Title/Dept: Professor Orthopedics & Rehabilitation
      Research: Human movement
    • Hrissanthi (Chris) Ikonomidou, MD, PhD
      Title/Dept: Professor Pediatric Neurology
      Research: Brain development
    • Bermans Iskandar, MD
      Title/Dept: Professor Neurosurgery; Director Pediatric Neurosurgery Program
      Research: Craniofacial repair, brachial plexus reconstruction, endoscopic surgery
    • Daniel Jackson, MD
      Title/Dept: Assistant Professor Pediatrics
      Research:  Pediatric allergy, asthma, immunology
    • Nizar Jarjour, MD
      Title/Dept: Professor Medicine Allergy & Clinical Immunology, Pulmonary & Critical Care
      Research: Pulmonary and critical care medicine
    • KyungMann Kim, PhD
      Title/Dept: Professor Biostats & Medical Informatics
      Research: Sequential methods of statistical analysis
    • Lingjun Li, PhD
      Title/Dept: Professor Pharmacy, Pharmaceutical Sciences and Chemistry
      Research: Peptide hormones, neurotransmitters
    • Glenn Liu, MD
      Title/Dept: Associate Professor Medicine, Hematology
      Research: Genitourinary oncology, experimental therapeutics
    • Sameer Mathur, MD, PhD
      Title/Dept: Associate Professor Medicine, Allergy & Clinical Immunology
      Research: Human peripheral blood eosinophils and epithelial cells
    • Eneida Mendonça, MD, PhD
      Title/Dept: Associate Professor Biostats & Medical Informatics
      Research: Medical/clinical informatics
    • David O’Connor, PhD
      Title/Dept: Professor Pathology & Laboratory Med, WI Primate Research Center
      Research: HIV/AIDS pathogenesis
    • David Page, PhD
      Title/Dept: Professor Biostats & Medical Informatics, Computer Science
      Research: Machine learning and data mining
    • Robert Pearce, MD, PhD
      Title/Dept: Professor & Dept Chair Anesthesiology
      Research: Anesthetics and other drugs’ control of memory and consciousness
    • G. Mark Pyle, MD
      Title/Dept: Professor Surgery
      Research: Monitoring during acoustic neuroma surgery; outcome studies in the surgical treatment of vertigo; measurements of middle function; development of cochlear and vestibular aqueducts
    • David Rabago, MD
      Title/Dept: Associate Professor Family Med
      Research: Chronic musculoskeletal pain, nasal saline irrigation
    • Amish Raval, MD
      Title/Dept: Associate Professor Cardiovascular Med
      Research: Interventional image guidance for complex catheter-based procedures
    • Scott Reeder, MD, PhD
      Title/Dept: Professor Chief Radiology
      Research: Liver diseases, new MRI methods
    • Nasia Safdar, MD, PhD
      Title/Dept: Associate Professor Infectious Disease
      Research: Healthcare Associated Infections
    • Nader Sheibani, PhD
      Title/Dept: Professor- Opthalmology, Pharmacology
      Research: Diabetic retinopathy, retinopathy of prematurity
    • Maureen Smith, MD, MPH
      Title/Dept: Professor Population Health, Family Medicine, Surgery
      Research: Short/long-term health outcomes in patients with diabetes
    • Paul Sondel, MD, PhD
      Title/Dept: Professor Pediatric Oncology, Immunology and Immunotherapy
      Research: Graft-versus-leukemia reactions, activation of anti-tumor immune destruction
    • Christine Sorkness, PharmD
      Title/Dept: Professor Pharmacy Practice
      Research: Efficacy and safety of therapeutic agents for asthma and allergic diseases
    • Marulasiddappa Suresh, DVM, PhD
      Title/Dept: Professor Pathobiological Sciences
      Research: T cell memory, CD8+ T cell responses in chronic viral infections
    • Susan Thibeault, PhD
      Title/Dept: Professor Surgery (Otolaryngology), Communication Sciences and Disorders
      Research: Molecular and genetic factors as basis of normal vocal fold tissue and its vibration
    • David J. Vanness, PhD
      Title/Dept: Associate Professor Population Health Sciences
      Research: Health Economics of Breast Cancer Therapies
    • Arnold Wald, MD
      Title/Dept: Professor Gastroenterology
      Research: Constipation, incontinence
  • Other Information

    The Graduate Program in Clinical Investigation admitted its first MS and PhD students in 2009. The program was made possible by the 2007 funding for UW ICTR from a National Institutes of Health Clinical and Translational Science Award.

    Graduate Program in Clinical Investigation Academic Policies and Procedures Handbook (PDF)